MEBO與SD-Ag乳膏治療放射性燒傷臨床對比研究

摘要： 目的多年來人們一直主張采用磺胺嘧啶銀(SD-Ag)乳膏或抗菌藥物乳劑治療放射性燒傷,但該方法療程偏長,有些患者因久治不愈形成慢性潰瘍,本研究旨在比較濕潤燒傷膏(MEBO)與磺胺嘧啶銀(SD-Ag)乳膏治療水皰型放射性燒傷的臨床療效,尋找有效的治療方法。方法在2006年6月至2010年6月期間,采用隨機分組表分組法,對水皰型放射性皮膚燒傷創(chuàng)面分別采用MEBO和SD-Ag乳膏治療,前者為MEBO組,共計36例(處),后者為SD-Ag組,共計30例(處);主要觀察指標為各組創(chuàng)面自行愈合時間和接受植皮手術(shù)的創(chuàng)面?zhèn)€數(shù),以及創(chuàng)面所發(fā)生的特殊變化。結(jié)果 MEBO組(36處)中有34處自行愈合,占總創(chuàng)面?zhèn)€數(shù)的94.4%,自愈創(chuàng)面的平均愈合時間為33.4 d±6.5 d,另2例經(jīng)過清創(chuàng)、移植自體皮膚封閉創(chuàng)面,植皮創(chuàng)面?zhèn)€數(shù)占本組創(chuàng)面?zhèn)€數(shù)的5.6%;SD-Ag組(30處)中有22處自行愈合,自愈創(chuàng)面的平均愈合時間為41.2 d±9.9 d,另8例(處)經(jīng)過清創(chuàng)、移植自體皮膚封閉創(chuàng)面,植皮創(chuàng)面?zhèn)€數(shù)占本組創(chuàng)面?zhèn)€數(shù)的25.7%。結(jié)論 MEBO治療水皰型放射性燒傷的臨床療效優(yōu)于SD-Ag乳膏,可明顯縮短創(chuàng)面愈合時間,降低手術(shù)幾率。
Objective SD - Ag ointment or antibiotic emulsion has always been applied as the therapy for radioactive burn injuries over the past years.Due to the delayed course of treatment,some patients are likely to develop chronic ulcers.This study is aimed to compare the therapeutic effects of MEBO Wound Ointment and SD - Ag in the treatment of blistered radioactive burn injuries in order to find an effective method.Methods From June 2006 to June 2010,66 cases of blistered radioactive burn injuries were randomized into MEBO group(36 wounds) and SD - AG group(30 wounds), with MEBO Wound Ointment and SD - Ag applied in the two group respectively.The observation indicators included time of self - healing,numbers of wounds receiving skin - grafting surgery and the specific changes of wounds.Results In MEBO group(36 wounds ),34 wounds were self - healed,counting up to 94.4%of total with the average duration of healing being 33.4±6.5 days,and the other two wounds were cured by means of debridement and auto - grafting,counting up to 5.6%; in SD - Ag group,22 wounds were self - healed with the average duration of 41.2±9.9 days,and the other 8 cases (wounds) were cured by means of debridement and auto - grafting,counting up to 25.7%.ConclusionThe therapeutic effect of MEBO Wound Ointment was superior to that of SD - Ag cream in treating blistered radioactive burn injuries with notable acceleration of wound healing and decreased rate of operation.