血清胱抑素C對急性心肌梗死存活患者近期預后的影響

摘要： 目的評價血清半胱氨酸蛋白酶抑制物C(Cystatin C,Cys C)對急性心肌梗死存活患者近期預后的預測價值。方法 2010年6月—2011年2月收治急性心肌梗死患者168例,根據(jù)入院24h內血清Cys C水平,分為正常血清Cys C組82例和高血清Cys C組86例,觀察2組患者Killip分級水平,2周內左室射血分數(shù),3個月內心血管事件,探討血清Cys C對急性心肌梗死存活患者近期預后的影響。結果高血清Cys C組在年齡、高血壓病史、陳舊性心肌梗死病史、Killip分級、3個月內心血管事件均顯著高于正常血清Cys C組(P<0.05),高血清Cys C組左室射血分數(shù)顯著低于正常血清Cys C組(P<0.05)。血清Cys C是急性心肌梗死存活患者3個月內發(fā)生心血管事件的獨立危險因素(OR=5.393,P=0.022)。結論血清Cys C是急性心肌梗死存活患者近期預后的預測因子。
Objective To evaluate the predictive value of Cystatin C(Cys C) for short - term prognosis in survival patients with acute myocardial infarction.Methods One hundred and sixty - eight patients with acute myocardial infarction admitted from June 2010 to February 2011 were enrolled and divided into the normal Cys C group with 82 cases and the high Cys C group with 86 cases according to the level of Cys C.The level of killip classification and the left ventricular ejection fraction were observed in the two groups during hospitalization,the cardiac events were observed in three months.The effects of Cys C on prognosis of survival patients with acute myocardial infarction were evaluated.Results The mean age,the history of hypertension,the history of old myocardial infarction,the level of killip classification,and the cardiac events in three months in high Cys C group were higher than those in normal Cys C group(P < 0.05).The left ventricular ejection fraction in high Cys C group was lower than that in the normal Cys C group(P <0.05).Multiple regression analysis indicated that the level of Cys C was an independent risk factor of cardiac events.Conclusion Cys C could predict short - term prognosis of survival patients with acute myocardial infarction.