依達拉奉聯(lián)合氯吡格雷治療急性腦梗死療效觀察

摘要： 目的觀察依達拉奉聯(lián)合氯吡格雷治療急性腦梗死的臨床療效。方法將符合納入標準的急性腦梗死患者120例按照隨機數(shù)字表法分為治療組和對照組,各60例。其中治療組采用依達拉奉聯(lián)合氯吡格雷治療,并與單獨使用氯吡格雷的對照組進行療效比較。結(jié)果治療后第60天2組神經(jīng)功能缺損評分差異有統(tǒng)計學意義(P<0.05);治療組的基本痊愈率和總有效率均明顯高于對照組(P<0.05);治療后7d全血比黏度、血漿比黏度、全血還原比黏度2組相比差異有統(tǒng)計學意義(P<0.05)。結(jié)論依達拉奉聯(lián)合氯吡格雷治療急性腦梗死有明顯療效,能有效改善神經(jīng)功能缺損,可有效降低血液黏稠度,恢復日常生活能力,具有實用性、安全性高,不良反應少,療效好等優(yōu)點,是治療急性腦梗死安全有效的藥物聯(lián)合,值得臨床推廣應用。
Objective To investigate the clinical efficacy of clopidogrel combined with edaravone in treatment of acute cerebral infarction.Methods A total of 120 cases of acute cerebral infarction were randomly divided into treatment group and control group,the treatment group was treated with clopidogrel and edaravone,while the control group was treated with clopidogrel alone.The clinical efficacy was compared between the two groups.Results The neurological deficit scores were significantly different between the two groups 60 days after treatment(P <0.05).The basic recovery rate and total effective rate of the treatment group were significantly higher than the control group(P < 0.05 ).The whole blood specific viscosity,blood plasma specific viscosity,whole blood reduced specific viscosity, packed cell volume of the treatment group were significantly different from the control group 7d after treatment(P < 0.05 ).Conclusion Edaravone in combination with clopidogrel in the treatment of acute cerebral infarction has a significant effect,can effectively improve neurological function,reduce blood viscosity,restore activities of daily living.The combined treatment is valuable,safe with little adverse reaction and it is worthy of clinical application.