大鼠接受不同運(yùn)動(dòng)刺激后高嶺土攝取量分析(英文)

摘要： 目的分析選擇不同運(yùn)動(dòng)方式作用于大鼠的前庭感受器后,誘導(dǎo)高嶺土攝取量變化作為運(yùn)動(dòng)病指標(biāo)的有效性。方法大鼠隨機(jī)分成5組,其中3組分別經(jīng)過沿耳間軸(IA)、頭尾軸(AP)進(jìn)行的直線加速運(yùn)動(dòng)和雙軸旋轉(zhuǎn)運(yùn)動(dòng)(DR)刺激,另2組用于對照組。實(shí)驗(yàn)時(shí)記錄刺激前、后各3d的高嶺土攝取量,并對數(shù)據(jù)做統(tǒng)計(jì)學(xué)分析。結(jié)果本研究觀察到:1)進(jìn)行IA、AP和DR刺激后,上述各組分別有25%、17%和58%的大鼠在刺激后3d高嶺土攝取量較之刺激前3d的平均增加1g以上;2)與有些報(bào)道不同,本研究中刺激后高嶺土攝取量的增加持續(xù)1d以上。結(jié)論3種運(yùn)動(dòng)刺激模式均可作為選擇性刺激前庭感受器官后誘導(dǎo)大鼠增加攝取高嶺土的方法,其中雙軸旋轉(zhuǎn)運(yùn)動(dòng)刺激最為有效。
Objective To analyze the efficacy of kaolin intake amount as an index for motion sickness(MS)induced by different motion patterns stimulating the vestibular receptors of rats.Methods Rats were randomly divided into 5 groups.Three groups were subjected to one of the following stimulations,respectively-linear acceleration along either the interaural axis(IA)or body axis(AP),and double rotation(DR)stimulation.Other 2 groups were used as control.Kaolin intake was recorded for consecutive 6 d,3 d before and 3 d after stimulation,and the data were statistically analyzed.Results It was found that:1)following IA,AP and DR stimulations,25%,17% and 58% of the rats in each group increased mean kaolin intake by 1 g in the 3 d phase post-stimulation compared with that in the same duration of pre-stimulation,respectively;2)in contrast to some previous reports,the present observation showed that high level of kaolin intake post-stimulation may persist for more than one day.Conclusion All 3 types of stimulation methods can serve as ways of specifically stimulating vestibular end-organs to induce kaolin intake increase,and double rotation is the most effective.