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ArmedTcellswithCARforcancerimmunotherapy

ScienceChina(LifeSciences) 頁數(shù)： 2 2016-04-05
摘要： Thedevelopmentofgeneticengineeringhasenabledthemodificationofstemcellsandsomaticcells.Tcellsexertimmuneresponsesagainstcancercells.EffortstoredirectTcellspecificityofachimericantigenreceptor(CAR)toadesiredantigenbeganinthe1990s(Grossetal.,1989;Kuwanaetal.,1987).In2006,thefirstclinicaltrialusingcarbonicanhydraseIXCAR-Tcellstofightrenalcancerwasconducted(Lamersetal.,2006).Until2011,Porteretal.exploitedCD19CAR-Ttotreatrefractory/relapsedchroniclymphoidleukemia(Porteretal.,2011).Subsequently,trials （共2頁）

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